Kate Williams try gives Wales early lead but Italy reply through Sofia Stefan's try and the boot of Michela Sillari, only for Gwenllian Pyrs to score on stroke of half-time to retake lead for Wales.
Francesca Granzotto twice, Silvia Turani, Vittoria Minuzzi and Aura Muzzo cross as Italy take control after break; Wales' misery compounded by Natalia John's late sin bin for head-on-head contact.
Game moved back a day from Saturday due to the funeral of Pope Francis.
Live Reporting
Matt Lloyd
Postpublished at 37 mins
37 mins
Italy 10-5 Wales
Veronica Madia is such a threat with that little chip over the top of the on-rushing Welsh defence.
Italy's attack just fumbles but it's fingertip stuff and one of these attacks is going to stick soon.
Some big hits by Georgia Evans and Kelsey Jones but Italy are so quick in getting the ball out of the tackle with their offloads that they're still a threat.
Wales run through an attack move as Hannah Jones trucks it up the middle and Lleucu George spins the ball wide to Jaz Joyce but it all comes to nothing as Italy's defence are first to the tackle.
Jaz Joyce briefly wins the battle of the full-backs.
The Welsh 15 runs back a kick and beats the first tackler - as she so often does.
Italy's Minuzzi knocks on attempting to field a spiralling high kick and Wales win a penalty that they kick to the corner - but Italy defend the rolling maul well and the chance is gone.
The Wales full-back runs back an Italian kick, steps past one defender and then just keeps those legs pumping in the next tackle and Wales win a penalty.