Kate Williams try gives Wales early lead but Italy reply through Sofia Stefan's try and the boot of Michela Sillari, only for Gwenllian Pyrs to score on stroke of half-time to retake lead for Wales.
Francesca Granzotto twice, Silvia Turani, Vittoria Minuzzi and Aura Muzzo cross as Italy take control after break; Wales' misery compounded by Natalia John's late sin bin for head-on-head contact.
Game moved back a day from Saturday due to the funeral of Pope Francis.
Live Reporting
Matt Lloyd
Postpublished at 2 mins
2 mins
Italy 0-0 Wales
Italy are the top carrying team in the Six Nations - but that's a knock-on and we have our first scrum just inside the Italian half.
Wales have the heavier pack... can they use that to their advantage?
Wales' faith in Lynn will pay off - Coxpublished at 11:29 British Summer Time 27 April
11:29 BST 27 April
Italy v Wales (11:30 BST)
Image source, Huw Evans Picture Agency
Wing Carys Cox insists Wales' players are fully behind Sean Lynn despite his miserable start as head coach.
Lynn won back-to-back Premiership titles with Gloucester-Hartpury before taking over Wales in March.
But he is still waiting for his first Test victory, with Wales bottom of the Six Nations and fighting to avoid a winless campaign with only a trip to Italy to come.
Lynn insists he needs more time to change things around for the World Cup later this year as he attempts to bring in a more expansive game.
"Everyone has completely bought into what he is doing," said Cox.
"Sean has been brilliant, especially with the culture and atmosphere in the camp. Everyone is really enjoying being in the environment.
"No-one should expect results to happen straight away under a new coach. But we're confident that with a little more time with him, performances are going to come over the coming months and then the World Cup."
Postpublished at 11:29 British Summer Time 27 April
11:29 BST 27 April
Italy v Wales (11:30 BST)
Elinor Snowsill Former Wales fly-half on BBC Radio Wales
I think there'll be a lot of tries to be honest.
Both teams have quite high missed tackle rates across the tournament, but also like to play attacking rugby.
Wales more in the Italians' half, Italy will attack from anywhere, we saw it against France last week, and they were actually beating France at half time and put in a really good 60-minute performance against them.
The tournament has completely been thrown open, Italy beat Scotland, Scotland beat Ireland.
There's not much consistency in performances across the teams which means it's very exciting and anything can happen on the day so I'm really looking forward to it today.
Lynn warns players to respond or face World Cup axepublished at 11:25 British Summer Time 27 April
11:25 BST 27 April
Italy v Wales (11:30 BST)
Image source, Huw Evans Picture Agency
Wales head coach Sean Lynn has warned World Cup places are on the line for his players over the next three games.
With his side bottom of the Six Nations and winless before the final game of the tournament against Italy on Sunday, Lynn pulled no punches over what is at stake in Parma.
And, with this summer's forthcoming World Cup, he was not afraid to shake up what has been a long-settled squad if they do not show an immediate response to four defeats in a row.
"These are pressure moments, this is where I'm going and I want to see if these individuals can handle it because I've got a World Cup coming up," said Lynn.
"There are World Cup places on the line over the next three games - away to Italy and the tour to Australia - and World Cup selection is not at all done.
"Sunday is like cup rugby. I'm looking for a response because the World Cup is all about pressure moments and you have to enjoy that and embrace it."
Match factspublished at 11:17 British Summer Time 27 April
11:17 BST 27 April
Italy v Wales (11:30 BST)
Image source, Getty Images
Italy haven't won at home in the Women's Six Nations since 2023 (v Ireland), with their last two victories both coming on the road. The Azzurre's run of five straight home defeats is their longest such run in the championship.
Wales have won three of their last four round-five games in the championship
Italy have made the most carries (555) and tackles (704) of any side in this tournament. Wales have made the fewest carries (388) and the fourth-most tackles (582).
Wales' Georgia Evans has completed the most tackles of any player in the 2025 Six Nations (76), while Italy's Sara Tounesi (11), Beatrice Veronese (9), and Alyssa D'Incà (9) have made the most dominant tackles of any players.
Wales have been successful from seven of their nine place-kick attempts in this year's championship (78%) — the best success rate of any side in 2025. Italy, by contrast, have the lowest success rate (36%).
View from the camp - Walespublished at 11:12 British Summer Time 27 April
11:12 BST 27 April
Italy v Wales (11:30 BST)
Image source, Huw Evans Picture Agency
Wales captain Hannah Jones said: "We've reflected on Ireland and we're disappointed as a team that we lost by that margin.
"Our discipline wasn't the best, the set piece, we're normally better in that area.
"Italy like to play a running game, they don't kick that often so we're definitely going to have to work hard, we have to turn up in all areas, do our individual roles to come together as a squad.
"We've talked about the journey and where we'd like to head going into a World Cup. I think having a win on the weekend will definitely give us confidence going to Australia [for a two-game summer tour].
"We have had small wins during the campaign so it's not all doom and gloom."
View from the camp - Italypublished at 11:09 British Summer Time 27 April
11:09 BST 27 April
Italy v Wales (11:30 BST)
Image source, Getty Images
Italy full-back Ostuni Minuzzi was a try-scorer in Cardiff last year.
"We were disappointed with the match against Wales last year and since then we've taken a new course with a new coach," she said.
"We are looking ahead to this match without thinking about what happened in the past. We've talked about last year and put that behind us and this Sunday we want to show what we are capable of.
"They've [Wales] got some wonderful players and they've shown that they can challenge teams, so we have to be aggressive from the start.
"We need to stick to our strategies if we want to get on top on the pitch and think of the collective, not about individuals."