Kate Williams try gives Wales early lead but Italy reply through Sofia Stefan's try and the boot of Michela Sillari, only for Gwenllian Pyrs to score on stroke of half-time to retake lead for Wales.
Francesca Granzotto twice, Silvia Turani, Vittoria Minuzzi and Aura Muzzo cross as Italy take control after break; Wales' misery compounded by Natalia John's late sin bin for head-on-head contact.
Game moved back a day from Saturday due to the funeral of Pope Francis.
Live Reporting
Matt Lloyd
Postpublished at 48 mins
48 mins
Italy 10-12 Wales
Elinor Snowsill Former Wales fly-half on BBC Radio Wales
Clearly a bit of a change of tactic from Italy, they have kicked more in these few minutes of the second half than they did in the whole first half.
At the moment Wales are winning this kicking battle which is good to see.
First time Wales lead at breakpublished at 12:29 British Summer Time 27 April
12:29 BST 27 April
HT: Italy 10-12 Wales
Ceri Coleman-Phillips BBC Sport Wales reporter at Stadio Sergio Lanfranchi
Not only are Wales winning at half-time for the first time in the tournament, they've got a replacement bench packed with impact players.
Alex Callender and Carys Phillips will be champing at the bit to get on having started last weekend against Ireland.
It will be interesting to see when Sean Lynn makes the changes - but one thing that's for sure, Wales are going to need to be on it for the whole 80 minutes today or Italy will make them pay.
Again it stems from the lineout but Wales did what they didn't do last time. They kept it tight, kept their patience as Kelsey Jones and Gwen Crabb go close before the big prop burrows over from inches out to get the ball down on the line.
Bevan converts and somehow Wales are ahead at the break.