Big chance for Dortmund to go ahead as Karim Adeyemi crashes a shot off the crossbar from inside the box.

Aston Villa could become the ninth different English side to qualify for a Champions League quarter-final, which would be the most teams from a single nation to have done so.

England and Spain are currently level on eight quarter-finalists each.

Image source, BBC Sport

Arsenal make seven changes to the side that drew 1-1 against Manchester United in the Premier League.

Only David Raya, Gabriel, Declan Rice and Mikel Merino retain their places from Sunday, with the likes of Ben White, Oleksandr Zinchenko, Jorginho and Kieran Tierney, all starting.

Arsenal XI: Raya, White, Kiwior, Gabriel, Lewis-Skelly, Jorginho, Rice, Zinchenko, Sterling, Tierney, Merino.

Subs: Neto, Saliba, Partey, Odegaard, Martinelli, Timber, Trossard, Calafiori, Setford, Butler-Oyedeji, Kabia, Nwaneri.

Image source, BBC Sport

PSV Eindhoven make five changes to the side that started their 2-1 Eredivisie win over Heerenveen last Saturday.

PSV Eindhoven XI: Benitez, Ledezma, Obispo, Nagalo, Malacia, Schouten, Babadi, Til, Driouech, Perisic, Bakayoko.

Subs: Karsdorp, Flamingo, Dest, De Jong, Lang, Drommel, Boscagli, Bajraktarevic, Veerman, Schiks, Land.

Matthew Upson
Former Arsenal and Brighton defender on BBC Radio 5 Live

It was a shame for Club Brugge to lose 3-1 because they played really well and probably should've been ahead when Villa got their second, and then the really loose penalty for the third made this game so difficult for them to approach.

They're going to have to come out and have a real go and that could play into Villa's hands here this evening.

Former Manchester City striker Julian Alvarez starts for Atletico Madrid. Pablo Barrios also starts.

Atletico Madrid XI: Oblak, Llorente, Gimenez, Lenglet, Mandava, Simeone, De Paul, Barrios, Gallagher, Griezmann, Alvarez.

Subs: Musso, Azpilicueta, Sorloth, Correa, Lemar, Samuel Dias, Molina, Riquelme, Witsel, Galan, Le Normand, Kostis.

Thibaut Courtois comes back into goal for Real Madrid after not starting at the weekend.

Jude Bellingham and Kylian Mbappe are also in the first XI as expected.

Real Madrid XI: Courtois, Valverde, Asencio, Rudiger, Mendy, Rodrygo, Tchouameni, Modric, Bellingham, Mbappe, Vinicius Junior.

Subs: Lunin, Gonzalez, Alaba, Camavinga, Guler, Endrick, Lucas, Garcia, Diaz, García, Ramon, Andres.

Serhou Guirassy runs through on goal and he's fouled by ex-Dortmund man Thomas Meunier in the box. Penalty to the visitors.

Image source, Reuters

Borussia Dortmund's Pascal Gross is booked for a foul and that means a one-match European ban - ie he'd miss the quarter-final first leg if Dortmund turn this around.

Hans Vanaken makes his 50th Champions League appearance for Club Brugge.

In fact he's played every Champions League game Club Brugge have been involved in since the 2016-17 campaign.

Nick Mashiter
BBC Sport football news reporter at Villa Park

Emi Martinez, Matty Cash, Ian Maatsen, Boubacar Kamara and Marcus Rashford are all handed recalls by Unai Emery.

Goalkeeper Martinez returns after missing the weekend's 1-0 win at Brentford with a minor injury while Marco Asensio is also back on the bench.

Aston Villa: Martinez, Cash, Konsa, Mings, Maatsen, McGinn, Tielemans, Kamara, Rashford, Watkins, Rogers

Subs: Disasi, Digne, Torres, Onana, Bogarde, Asensio, Bailey, Ramsey, Zych, Olsen

Club Brugge, second in the Belgian Pro League and nine points behind leaders Genk, are unchanged from their 3-1 win at Cercle Brugge on Sunday.

Club Brugge: Mignolet, De Cuyper, Ordonez, Mechele, Sabbe, Onyedika, Vanaken, Jashari, Tzolis, Jutgla, Talbi

Subs: Romero, Siquet, Spileers, Vetlesen, Nielsen, Vermant, Nilsson, Skoras, Campbell, Jackers

Second half under way.

Borussia Dortmund have lost 15 of their last 17 games in the Champions League in which they've been behind at half-time.

Garry Thompson
Former Aston Villa forward on BBC Radio 5 Live

These are special nights at Villa Park. We beat Bayern Munich and the atmosphere that night was superb. A night game at Villa Park is very, very special, and in the Champions League there's an added bonus to it.

The fact that we're playing again tonight and this could take us into the quarter-finals, the place is buzzing, people are really looking forward to it.

For a lot of the players it's a new experience for them. As soon as Unai Emery walked in here, for the last two years we've been improving.

We've got to the point where we got to the Conference League, into the Champions League and we are improving in the Champions League.

Basically, it is an adventure at the minute. They're enjoying the adventure and hopefully, it continues for a long while to come.

Image source, Getty Images

Villa have progressed from 12 of their previous 14 European ties when they have won the first leg.

The exceptions are against Inter Milan in 1990-91 and Celta Vigo in 1998-99 - both in the Uefa Cup.

Arsenal fan Alan Alger speaking to BBC Radio 5 Live: "Without taking anything away from the lads for the Netherlands trip, that was an amazing performance, but it was against a side that probably hasn't scouted us as well as Premier League clubs.

"It all comes down to knowing your enemy and fortunately PSV didn't know us too well [last week] and played into our hands.

"We are enjoying this competition and this part of the season but everything else has been a bit upside down and we have not got the results we were expecting."

Lille are 45 minutes away from the quarter-finals. Somehow.

Dortmund have had six shots on target - with Lille scoring from their only one.

Image source, Reuters