Team news
Newcastle United are still without Anthony Gordon, who will complete a three-match ban on Wednesday.
The 24-year-old winger also sustained a minor thigh problem on international duty and is a doubt for next week's trip to Leicester.
Defensive trio Sven Botman, Lewis Hall and Jamaal Lascelles remain long-term absentees.
Brentford defender Michael Kayode will return to the squad after two games out with a knee issue.
Mathias Jensen is ruled out because of illness, while Fabio Carvalho is expected to miss the remainder of the season after undergoing shoulder surgery.
Match facts
Head-to-head
Newcastle lost 5-2 in their first home match against Brentford in 1934 but are since unbeaten in nine league and cup encounters at St. James' Park, winning eight and drawing one.
Brentford are vying to complete a second league double over the Magpies, and first since 1934-35.
The previous seven Premier League meetings have produced an average of 4.3 goals per game.
Newcastle United
Newcastle have lost three of the past five league and cup fixtures at St. James' Park, including their most recent outing against Brighton in the FA Cup.
However, they have won nine of their last 13 Premier League games, losing four.
Eddie Howe's side have dropped just seven points from winning positions this season, the fewest of any Premier League club.
Newcastle have also gained 18 points from losing positions so far this term - only leaders Liverpool, with 19, have fared better.
They have conceded with the first shot they have faced nine times in the Premier League this season.
Alexander Isak has scored nine top-flight goals at home this season and 10 on the road; he could become the third Newcastle player to register double figures home and away in the same Premier League season, emulating Andrew Cole in 1993-94 and Alan Shearer in 2001-02.
Brentford
Brentford are on a run of five successive league away wins, their longest since December 2010 in League One.
Their most recent away defeat was at Newcastle in an EFL Cup quarter-final in December.
The Bees have scored with their first shot nine times in the Premier League this season, the most of any side.
Yoane Wissa has a career-high 14 goals in the top flight this season, while he's also the first Bees player to score 40 goals in the Premier League.
Wissa has scored in three of his last four Premier League appearances, including both of his last two away from home.