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Coutinho hat-trick, Mane (2), Firmino & Salah for dominant Liverpool
Liverpool win Group E
Llorente, Son & Nkoudou for Spurs lead against APOEL Nicosia
Bernard strike & Ismaily goal for Shakhtar, late Aguero penalty for Man City
Ah the glory days of the mid 2000s, when Premier League sides reached the Champions League final as a matter of course.
Image source, BBC SportIt has been six seasons since an English team reached the final, when Chelsea somehow beat Bayern Munich in 2012. Our live text broke and I basically had to do it in a word document.
Great days.
Is this year a time for the clubs to return to the summit?
Liverpool v Spartak Moscow (19:45 GMT)
Liverpool
Image source, Getty ImagesLionel Messi scored twice in one of Spartak's defeats on the road
Tottenham v Apoel Nicosia (19:45GMT)
Simon Stone
BBC Sport at Wembley
He may have changed virtually his entire team for tonight's game but the history books don't suggest Tottenham manager Mauricio Pochettino has anything to worry about at Wembley tonight.
Spurs have played Cypriot teams five times. They have won four and drawn one and have a combined score of 15-3.
Tottenham v Apoel Nicosia (19:45 GMT)
Tottenham boss Mauricio Pochettino makes eight changes to the team that started against Watford last time out as Georges-Kevin N'Koudou makes his first start of the season for the club.
Michel Vorm, Serge Aurier, Danny Rose, Juan Foyth, Harry Winks, Moussa Sissoko, Nkoudou and Fernando Llorente all come in.
Dele Alli, Davinson Sanchez and Son Heung-min are the only players to retain their places.
Tottenham XI: Vorm, Aurier, Sanchez, Foyth, Rose, Winks, Sissoko, Dele, Nkoudou, Son, Llorente.
Image source, .Shakhtar Donetsk v Manchester City (19:45 GMT)
Truly bizarre!
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Tottenham v Apoel Nicosia (19:45 GMT)
Image source, Getty ImagesHarry Kane scored a hat-trick when the sides met earlier this season
Liverpool v Spartak Moscow (19:45 GMT)
Liverpool
Manager Jurgen Klopp says the Anfield atmosphere "can help" Liverpool progress in the Champions League.
Liverpool will go through as group winners if they beat Spartak Moscow. They will also qualify for the last 16 with a draw.
WATCH MORE: Klopp hails 'main man' Woodburn
Tottenham v Apoel Nicosia (19:45 GMT)
Tottenham Hotspur
Image source, .Tottenham: Through as group winners in an impressive campaign including a win and a draw against defending champions Real Madrid.
Real Madrid: Qualify as runners-up.
Borussia Dortmund: Will qualify for the Europa League if Apoel lose at Tottenham. Otherwise need to match the Cypriots' result.
Apoel Nicosia: Will finish third if they avoid defeat by Tottenham and Dortmund lose at Real Madrid.
Shakhtar Donetsk v Manchester City (19:45 GMT)
Manchester City
Image source, .Manchester City: Through as group winners having won their first five matches, including an impressive 4-2 victory at Napoli.
Shakhtar Donetsk: Will go through as runners-up if they avoid defeat at home to Manchester City in their final match.
Napoli: Need to beat Feyenoord and hope City beat Shakhtar.
Feyenoord: Will finish bottom having lost all five of their matches.
Phil McNulty
BBC Sport chief football writer
Image source, PALiverpool have reported an alleged incident of racist abuse aimed at Rhian Brewster during a Youth League game with Spartak Moscow on Wednesday to Uefa.
Brewster, the Golden Boot winner when England won the under-17 World Cup in October, was visibly angry at being targeted by a Spartak defender and had to be pulled away by team-mates and staff at the end of Liverpool's 2-0 win.
The 17-year-old reported the alleged incident to match officials at the game played at Tranmere Rovers' Prenton Park stadium and Liverpool have followed standard procedure by also reporting it to Uefa.
It is the second time this season that a game between Liverpool and Spartak has ended with allegations of racist abuse after Nigerian-born forward Bobby Adekanye was subjected to chants and gestures from home fans in Moscow in September.
Spartak were found guilty and Uefa ordered the club to close at least 500 seats for the their next Youth League game played at their academy stadium.
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Will Liverpool make it a comfortable evening for their fans? All five Premier League clubs safely through?
Or will Spartak throw a spanner in the works?
Image source, Getty ImagesLiverpool have failed to qualify from the group in their last two campaigns
Fire over your pre-match thoughts to 81111 (UK Only) or tweet us at #bbcfootball
Liverpool v Spartak Moscow (19:45 GMT)
Liverpool
Liverpool: Will go through as group winners if they beat Spartak Moscow at Anfield in their final game. Will also qualify for the last 16 with a draw.
Sevilla: Will definitely qualify with victory over Maribor and will go through with a draw if Spartak do not beat Liverpool. If Liverpool lose or draw and Sevilla win, the Spanish side will top the group.
Spartak Moscow: Victory at Anfield would take them through but anything less will mean they drop into the Europa League.
Maribor: Will finish bottom of the group having collected two points from their first five games.
Tottenham v Apoel Nicosia (19:45 GMT)
Tottenham Hotspur
As you'd expect there's no Harry Kane tonight though. Spurs make eight changes as just Davinson Sanchez, Dele Alli and Son keep their places from the weekend.
There are rare starts for Georges-Kevin Nkoudou and Juan Foyth.
Tottenham v Apoel Nicosia (19:45 GMT)
Shakhtar Donetsk v Manchester City (19:45 GMT)
Manchester City
Phil Foden starts for Manchester City as Pep Guardiola quite sensibly rests his squad before the weekend's derby.
There are seven changes in all from the team which beat West Ham.
Liverpool v Spartak Moscow (19:45 GMT)
Liverpool
Liverpool make five changes from the team which beat Brighton as Philippe Coutinho is named captain.
Sadio Mane returns to the starting line-up.
Full team news to follow.
Liverpool v Spartak Moscow (19:45 GMT)
It may surprise you - it surprised me - but Liverpool haven't played a knockout game in the Champions League since a stonewall classic 4-4 draw at Stamford Bridge in April 2009.
Remember that?
Chelsea won 7-5 on aggregate as there ended up being three Premier League teams in the semi-finals.
Image source, Getty ImagesBarcelona still won it.
Liverpool v Spartak Moscow (19:45 GMT)
Draw at home to Spartak Moscow tonight and Liverpool will make it an unprecedented five Premier League teams in the last 16 of the Champions League.
Image source, Getty ImagesBeat Spartak Moscow at home and Liverpool will win their group too. They don't have Neil Mellor any more, but they shouldn't really need him this evening.
Image source, Getty ImagesAll set?