Immediately, Ireland have an opportunity to strike back.

Huw Jones guddles the kick-off into touch and the Irish have a scrum on the home 22.

Chris Paterson
Former Scotland international on BBC One

We have seen the Ireland defence dominating phases so often, but they cannot come forward too quickly because Scotland have so many options.

Image source, Reuters

Tony Ward
Former Ireland fly-half on BBC Radio Ulster

I had expected to see Ireland hit the ground running but if anything it is Scotland who got off to a good start.

Just a couple of early concerns: Hogg's excellent kick-off compared to Murray's first box kick and then Josh Strauss running over Bundee Aki.

Over she goes. Scotland lead, and deservedly so.

Image source, Reuters

Scotland use their forwards and inch ever closer to the Irish line.

Bundee Aki thunders into a ruck and scoops up the ball illegally - another Scottish penalty in front of the posts.

This time, Greig Laidlaw points to the sticks.

Scotland have started really strongly, playing with speed and aggression and pinning Ireland back in their own 22.

Johnny Sexton tackles Ryan Wilson high - rather than go for the posts, Scotland boot it to the corner.

First big chance for points here...

Josh Strauss makes the first big ball-carrying rumble of the game, steamrolling a would-be tackler.

Scotland need plenty of that from their hulking number eight today.

Huw Jones kicks downfield and Ireland have a line-out deep inside their own 22.

Image source, Reuters

Here we go...

Stuart Hogg gets us under way

Chris Henry
Former Ireland flanker on BBC Radio Ulster

Schmidt needed to freshen things up this week so he was probably helped by all the injuries.

I feel like some of the players that didn't feature against England have benefited the most. Rob Kearney, for example, with his experience will have a chance to show he can firm up the backfield today.

Image source, Inpho

Peter Wright
Former Scotland prop on BBC Radio Scotland

Andy Nicol
Former Scotland international on BBC One

Every team is going to target the number 10. England's third or fourth defender kept coming at Johnny Sexton with great angles last week and he wasn't give any time.

I'm not letting the rabbit out of the hat by saying Scotland will target him today.

Key to this game will be the battle between stand-offs Finn Russell and Johnny Sexton.

The swashbuckling Scot versus the ultra-intense world player of the year.

Russell plays with flamboyance and is flourishing at Racing 92 after joining the Parisian club from Glasgow Warriors in the summer. He seems to have rid the inconsistencies from his game in France.

The fly-half shone against Italy with two delightful kick assists and some excellent decision-making under pressure. You can bet the Ireland defence will try to disrupt his play-making flow.

Sexton is ruthless and orchestrates a more structured - and effective - Ireland game plan. A two-time British and Irish Lion, he has won three Pro14s, four European Champions Cups and three Six Nations titles.

England prevented the Leinster man exerting his usual imperious influence last week. Getting Russell front-foot ball and stifling Sexton will be key to Scotland's chances of success.

Image source, Getty Images/SNS

The teams are out at Murrayfield. A hush falls over the stadium as players and fans prepare to belt out the anthems...

Andy Nicol
Former Scotland international on BBC One

Gregor Townsend wants his best players for the biggest games. Sean Maitland is one of those players that the rest of the boys will get a boost from seeing line-up. Blair Kinghorn will win many more caps but Maitland is the number one winger.

Scotland captain Greig Laidlaw needs 10 more points to overtake the great Gavin Hastings and become his country's second-highest point-scorer.

The little scrum-half has 658 to show for his 67 caps to date.

Top spot is some way off, though. Chris Paterson's benchmark of 809 will take some bettering.

Laidlaw kicked the winning penalties two years ago when Scotland won this fixture

BBC One

Scotland head coach Gregor Townsend: "It makes no difference that Ireland lost last week because they would have been targeting a second Grand Slam in a row had they won. They are a top quality team.

"England played very well tactically and they put pressure on Ireland, but they are a different team to us and we have our won way of playing, which we believe can beat any team in the world.

"We have some excellent players. Simon Berghan and Jonny Gray come back into the team so we are just as strong as last week."

Kelly Brown
Former Scotland captain speaking to BBC Sport

England just physically battered Ireland. The telling stat was the number of dominant tackles - 49 to six. Ireland just couldn't cope with the brutality.

Scotland are a very, very different team. England have got four or five absolute monsters - you talk about Mako and Billy Vunipola, Manu Tuilagi, Itoje - they have some huge physical beasts.

Scotland probably don't quite have the size. But they will have the intent, they will need to really front up in defence, and then when we get a chance to attack, I'd expect Scotland to attack in a very, very different way to England.

England used the kicking game a lot and put the ball in behind Ireland - we need to do that at the right times, but I think Scotland will look to inject a bit more tempo into the game.

The last time Ireland lost two on the bounce? June 2016 when a promising start to a three-Test tour of South Africa unraveled against the Springboks.

Rory Best, Conor Murray, Tadhg Furlong and Quinn Roux are the sole survivors from the Irish team that started the second Test in Johannesburg as the Boks came from 16 points behind at half-time to level the series.

Roux made his Ireland debut that day at Ellis Park but he has had to wait until now for his first Six Nations start.

The Connacht lock was omitted from Ireland's initial Six Nations squad but following injuries to Devin Toner, Iain Henderson and Tadhg Beirne the powerful Connacht lock will take responsibility for calling the Irish line-outs this afternoon.

Image source, Inpho

Paul O'Connell
Former Ireland captain on BBC One

It is a big loss. He has a lot of experience in terms of running and calling the line-out. It is a worry but it is also an opportunity as well.

There are a few players who have been ever-present under Joe Schmidt and he is one of them.

It is a chance to give someone an opportunity to develop with the World Cup in mind. But it’s not ideal timing coming off the back of a loss.

Tom English
BBC Scotland's chief sports writer

Gregor Townsend has injuries - John Barclay and Hamish Watson are grievous losses in terms of how Scotland want to play the game - but so have Ireland. Many of them.

Their first-choice centres - Garry Ringrose and Robbie Henshaw - are out. Their biggest ball-carrier - CJ Stander - is also out. Iain Henderson, Tadhg Beirne and Devin Toner - three of their top four locks - are injured. Their squad is incredibly deep and they still have all sorts of artillery, but the pressure is all on Ireland.

Grand Slam champions last year. Conquerors of New Zealand. World number two. World Cup hopefuls. Losing to Scotland, as they've done in two of their last three visits to Edinburgh, would set the distress flares shooting out from the top of the Wicklow hills and all points west, south and north. It's a game they have to be worried about.